Effects of 90 Days of Resveratrol Supplementation on Cognitive Function in Elders: A Pilot Study.

July 01, 2018•1 min read

J Altern Complement Med. 2018 Jul;24(7):725732. doi: 10.1089/acm.2017.0398. Epub 2018 Mar 27.

Effects of 90 Days of Resveratrol Supplementation on Cognitive Function in Elders: A Pilot Study.

Anton SD , Ebner N , Dzierzewski JM , Zlatar ZZ , Gurka MJ , Dotson VM , Kirton J , Mankowski RT , Marsiske M , Manini TM .

Abstract

OBJECTIVE: The purpose of this trial was to study the effects of chronic resveratrol use on cognitive function in humans.

DESIGN: The authors conducted a doubleblind, Phase IIa randomized, placebocontrolled trial to obtain preliminary estimates of the effects of resveratrol supplementation on cognitive function over a 90day period in older adults.

LOCATION: University of Florida in Gainesville, FL.

SUBJECT: Sedentary, overweight older adults (N = 32; age range: 6593 years, M age = 73.34 years, SD age = 7.02 years).

OUTCOME MEASURE: Cognitive function was assessed before and after treatment using a wellcharacterized test battery: Trail Making, Digits Forward and Backward, EriksonFlanker, Controlled Oral Word Association, Hopkins Verbal Learning TestRevised, and Task Switching.

RESULTS: Psychomotor speed improved on the Trail Making Test part A in participants taking 1000 mg/day of resveratrol compared with participants in both the 300 mg/day condition and the placebo condition (p = 0.02).

CONCLUSION: This pilot study suggests that 90 days of resveratrol supplementation at a dose of 1000/mg per day selectively improves psychomotor speed but does not significantly affect other domains of cognitive function in older adults. These findings provide modest support to further study the effects of resveratrol on cognitive function in older adults.

KEYWORDS: aging; botanical; brain; nutrient; performance; polyphenol; processing speed

PMID: 29583015 PMCID: PMC6065512 [Available on 20190701] DOI: 10.1089/acm.2017.0398 [Indexed for MEDLINE]

Format: Abstract Publication types, MeSH terms, Substances, Grant support

Link to the official publication

Stephen Anton, PhD

Dr. Anton’s specific research interests are in the role that lifestyle factors have in influencing obesity, cardiovascular disease, and metabolic disease conditions. He completed his doctoral degree in Clinical and Health Psychology at the University of Florida (UF), receiving training in health promotion and the delivery of lifestyle interventions designed to modify eating and exercise behaviors. Following completion of his post-doctoral fellowship at the Pennington Biomedical Research Center in June 2007, he accepted a joint Assistant Professor position within the Department of Aging and Geriatric Research and Department of Clinical and Health Psychology at the University of Florida. Since joining the University of Florida, he has successfully obtained and conducted multiple grants examining the effects that lifestyle-based interventions have on biological and functional outcomes relevant to obesity, cardiovascular disease, and metabolic disease conditions related to aging. With over 150 scientific articles and book chapters, his research has been recognized both nationally as well as internationally.

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