Wearable technology to reduce sedentary behavior and CVD risk in older adults: Design of a randomized controlled trial

December 20, 2017•2 min read

Contemporary Clinical Trials Communications journal homepage: www.elsevier.com/locate/conctc

Wearable technology to reduce sedentary behavior and CVD risk in older adults: Design of a randomized controlled trial

Lisa M. Krehbiel, Andrew S. Layne, Bhanuprasad Sandesara, Todd M. Manini, Stephen D. Anton, Thomas W. Buford∗

University of Florida, Gainesville, FL, USA

Abstract

ersons aged over 65 years account for over the vast majority of healthcare expenditures and deaths attributable to cardiovascular disease (CVD). Accordingly, reducing CVD risk among older adults is an important public health priority. Structured physical activity (i.e. exercise) is a well-documented method of decreasing CVD risk, but recent large-scale trials suggest that exercise alone is insufficient to reduce CVD events in high-risk populations of older adults. Thus adjuvant strategies appear necessary to reduce CVD risk. Accumulating evidence indicates that prolonged sedentary behavior (e.g. sitting) has detrimental health effects that are independent of engagement in recommended levels of moderate-intensity exercise. Yet clinical trials in this area are lacking. We hypothesize that exercise, when combined with a novel technology based intervention specifically designed to reduce sedentary behavior will reduce CVD risk among sedentary older adults. The purpose of this study is to evaluate the feasibility and efficacy of combining a traditional, structured exercise intervention with an innovative intervention designed to decrease sedentary behavior and increase non-exercise physical activity (NEPA). This study will provide us with critical data necessary to design and implement a fullscale trial to test our central hypothesis. Participants aged ≥60 years with moderate to high risk of coronary heart disease (CHD) events are randomly assigned to either the exercise and technology intervention (EX + NEPA) or exercise alone (EX) groups. Study dependent outcomes include changes in 1) daily activity patterns, 2) blood pressure, 3) exercise capacity, 4) waist circumference, and 5) circulating indices of cardiovascular function. This study will provide critical information for designing a fully-powered clinical trial, which could have health implications for the ever increasing population of older adults.

Link to the official publication

Stephen Anton, PhD

Dr. Anton’s specific research interests are in the role that lifestyle factors have in influencing obesity, cardiovascular disease, and metabolic disease conditions. He completed his doctoral degree in Clinical and Health Psychology at the University of Florida (UF), receiving training in health promotion and the delivery of lifestyle interventions designed to modify eating and exercise behaviors. Following completion of his post-doctoral fellowship at the Pennington Biomedical Research Center in June 2007, he accepted a joint Assistant Professor position within the Department of Aging and Geriatric Research and Department of Clinical and Health Psychology at the University of Florida. Since joining the University of Florida, he has successfully obtained and conducted multiple grants examining the effects that lifestyle-based interventions have on biological and functional outcomes relevant to obesity, cardiovascular disease, and metabolic disease conditions related to aging. With over 150 scientific articles and book chapters, his research has been recognized both nationally as well as internationally.

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